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Your Position: Home > IL-7 R alpha & TSLP R

IL-7 R alpha & TSLP R

Brief Information

Name:Interleukin-7 receptor subunit alpha
Target Synonym:Interleukin-7 receptor subunit alpha,Interleukin 7 Receptor Isoform H5-6,CDw127,IL-7R subunit alpha,IL-7RA,IL-7 receptor subunit alpha,CD127 Antigen,IL-7R-Alpha,Interleukin 7 Receptor Alpha Chain,CD127,IL7RA,ILRA,Interleukin-7 Receptor alpha Subunit
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

CHEK-ATF045-Cell-based assay
 IL-7 R alpha & TSLP R FACS

Co-expression analysis of human TSLP R and IL-7 R alpha on Human TSLP R (Luc) HEK293 Reporter Cell by FACS.
Cell surface staining was performed on Human TSLP R (Luc) HEK293 Reporter Cell or negative control cell using PE-labeled anti-TSLP R antibody and FITC-labeled anti-IL-7 R alpha antibody.

ILR-H525x-BLI
 IL-7 R alpha & TSLP R BLI

Loaded Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H525x) on Protein A Biosensor, can bind Human TSLP Protein, His Tag, premium grade (Cat. No. TSP-H52Hb) with an affinity constant of 1.16 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

ILR-H5255-BLI
 IL-7 R alpha & TSLP R BLI

Loaded Human IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-H5255) on Protein A Biosensor, can bind Human TSLP Protein, His Tag, premium grade (Cat. No. TSP-H52Hb) with an affinity constant of 134 pM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL7Ra,CD127,TSLP R,CRLF2,IL-XR,ILXR,p2RY8,CRLF2 fusion,TSLP receptor,TSLPR,CRL2,CRLF2Y,Cytokine receptor-like 2

Background

TSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Human TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PF-06342674 RN-168; PF-6342674; PF-06342674 Pfizer Inc Details
MDK-703 MDK-703 Phase 1 Clinical Medikine Inc Details
ASP-9801 ASP-9801 Phase 1 Clinical Astellas Pharma Inc Solid tumours; Neoplasms; Neoplasm Metastasis Details
Lusvertikimab OSE-127; S-95011 Phase 2 Clinical Effimune Sjogren's Syndrome; Colitis, Ulcerative Details
Interleukin-7 (Revimmune SAS) rhIL-7; CYT-107; CYT-99-007 Phase 2 Clinical Cytheris Urinary Bladder Neoplasms; Neuroectodermal Tumors, Primitive, Peripheral; Melanoma; Catheter-Related Infections; T-Lymphocytopenia, Idiopathic CD4-Positive; Leukemia, Myeloid, Acute; Hepatitis C; Ureteral Neoplasms; Urologic Neoplasms; Lymphopenia; Neuroblastoma; Sarcoma; Urethral Neoplasms; Prostatic Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Carcinoma, Transitional Cell; Coronavirus Disease 2019 (COVID-19); Mycobacterium Infections, Nontuberculous; Sepsis; Myeloproliferative Disorders; Myelodysplastic Syndromes; Hepatitis B, Chronic; Carcinoma, Renal Cell; Rhabdoid Tumor; Shock, Septic; Kidney Neoplasms; HIV Infections Details
Efineptakin alfa NT-I7; GX-I7; TJ-107 Phase 2 Clinical Genexine Inc Pancreatic Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma; Sarcoma, Kaposi; Carcinoma, Squamous Cell; Leukoencephalopathy, Progressive Multifocal; Gliosarcoma; Astrocytoma; Lymphopenia; Colorectal Neoplasms; Breast Neoplasms; Urinary Bladder Neoplasms; HIV Infections; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Coronavirus Disease 2019 (COVID-19); Papillomavirus Infections; Glioblastoma; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Merkel Cell; Esophageal Neoplasms; Solid tumours; Ovarian Neoplasms Details

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